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Mitochondria-targeting tetrapeptide

SS-31 (Elamipretide)

Mitochondria-targeting tetrapeptide for cardiolipin binding and ETC efficiency.

• Half-life~2 hours plasma
• Dose range5 to 40 mg subcutaneous · 8 to 12 week cycle
• Reconstituted stability28 days, 2–8 °C
• VerificationCOA included

Mechanism

How it works.

Selectively concentrates in inner mitochondrial membrane. Binds cardiolipin to support electron-transport-chain efficiency. Reduces mitochondrial ROS production.

Research

What the research shows.

Clinical research in mitochondrial myopathies, ischemia-reperfusion injury, and age-related macular degeneration. Longevity-research applications are the natural extension.

SS-31 (Elamipretide) is a synthetic mitochondria-targeting tetrapeptide. The compound binds cardiolipin in the inner mitochondrial membrane, enhancing electron-transport-chain efficiency and reducing oxidative stress.

The mitochondrial-targeting peptide class is one of the more interesting frontiers in longevity research. SS-31 has the most-developed clinical research base in the class.

Contraindications

When not to use.

Active malignancy. Pregnancy. Pediatric use without clinical oversight.

Optimal pairings

Stacks well with.

Coenzyme · Cellular energy + sirtuin pathway substrate NAD⁺ View → Mitochondrial-derived 16-amino-acid peptide (mitokine) MOTS-c View →

Tool Calculate dose → Reconstitution math + syringe units Tool Build a stack → Get a curated protocol with this compound Shop Buy SS-31 (Elamipretide) → COA included · cold-chain dispatched

Information is educational, derived from published research. Not medical advice. All compounds sold for research use only. Bloodwork and a clinical consultation should precede any new protocol.