ACTH(4-10) analog with Pro-Gly-Pro stabilisation
Semax
Russian cognitive peptide derived from ACTH(4-10) for focus and stress resilience.
- Half-life~30 minutes intranasal
- Dose range250 to 1000 mcg per spray, 2 to 3 times daily · 2 to 4 week cycle
- Reconstituted stability28 days, 2–8 °C
- VerificationCOA included
Mechanism
How it works.
Modulates BDNF, dopamine, and serotonin signalling. Direct neurotrophic effects on hippocampal and cortical neurons.
Research
What the research shows.
Russian clinical research shows meaningful effects in stroke recovery and vascular cognitive impairment. Healthy-adult effects are modest: improved attention regulation and stress resilience.
Semax is a heptapeptide derived from the ACTH(4-10) sequence with a Pro-Gly-Pro stabilising extension. The compound is approved in Russia for stroke recovery and cognitive impairment in vascular contexts.
The mechanism centres on BDNF modulation, monoamine signalling, and direct neurotrophic effects. In healthy adults, effects are modest and selective; not a stimulant.
Contraindications
When not to use.
Active mania or psychosis. Pregnancy. Pediatric use without clinical oversight.
Optimal pairings
Stacks well with.
Information is educational, derived from published research. Not medical advice. All compounds sold for research use only. Bloodwork and a clinical consultation should precede any new protocol.