Tripeptide α-MSH fragment (Lys-Pro-Val)
KPV
Tripeptide fragment of α-MSH studied for anti-inflammatory and antimicrobial effects.
- Half-lifeShort plasma; effect via cellular signalling persists
- Dose range200 to 500 mcg/day subcutaneous · 4 to 8 week cycle
- Reconstituted stability28 days, 2–8 °C
- VerificationCOA included
Mechanism
How it works.
Anti-inflammatory action via NF-κB pathway modulation. Antimicrobial activity. Gut-barrier supportive effects.
Research
What the research shows.
Animal-research data on inflammatory bowel disease and gut-barrier protection is strong. Antimicrobial activity confirmed in vitro. Human-research base is preliminary.
KPV (Lys-Pro-Val) is a synthetic tripeptide fragment derived from the C-terminus of α-melanocyte stimulating hormone (α-MSH). Studied for anti-inflammatory effects without the pigmentation activity of full α-MSH.
Research-context use focuses on inflammatory bowel-disease research models, gut-barrier integrity, and antimicrobial defence. The compound is small enough to be reasonably stable across multiple delivery routes.
Contraindications
When not to use.
Active autoimmune disease without clinical oversight. Pregnancy. Pediatric use without clinical oversight.
Optimal pairings
Stacks well with.
Information is educational, derived from published research. Not medical advice. All compounds sold for research use only. Bloodwork and a clinical consultation should precede any new protocol.